Computational Biologist - Protein Structure Modelling, DSP (m/f/d)

Beschreibung

Rentschler Biopharma is a leading global contract development and manufacturing organization (CDMO) for biopharmaceuticals. From our headquarters in Laupheim, Germany, and our site in Milford, MA, USA, we offer end-to-end solutions, including bioprocess development and manufacturing, as well as related consulting activities such as project management and regulatory support. In Stevenage, UK, we have launched Rentschler ATMP Ltd. dedicated to cell and gene therapies.

We are a family-owned company with approximately 1100 employees from 25 nationalities. What unites us at Rentschler Biopharma, is the passion for what we do. We empower our clients to help patients with serious or rare diseases. With our dedication and expertise, we convert medical research into outstanding biopharmaceuticals. Thus, we provide an important contribution to the global availability of essential therapies. Going forward, we are expanding our team to ensure our long-term sustainable growth. Join us and be part of a unique journey, shaping the future of biopharmaceutical manufacturing together!

• Evaluation and establishment of in silico protein structure model generation for different molecule classes, especially for antibodies, antibody-derived and other therapeutic proteins
• Involvement in the design and implementation of algorithms to interloop protein property information and purification process behavior
• Evaluation of innovative methodologies to contribute to the ultimate goal of building in silico DSP designs based on amino acid sequences only
• Design and development of scalable downstream processes from bench to commercial scale
• Transfer of customer downstream processes to the Rentschler process format

• Scientific collaboration with process development colleagues in the development of downstream processes enabling subsequent GMP production
• Scientific collaboration with external process development partners and internal data science experts in the development of new machine learning and hybrid modeling approaches in DSP development
• Cooperative communication, representation, and technical discussion with our customers in “face-to-face meetings”, conference calls, etc.
• Technical supervision of lab technicians and engineers in DSP development
• Subject matter expert in an interdisciplinary and cross-functional team with colleagues from manufacturing science and technology, data science unit, upstream process development, and regulatory affairs
• Participate in innovation and internal projects for driving progress of the group / company
• Review relevant chapters of CMC dossiers (IND/IMPD and BLA/MAA)

• Deep knowledge in protein structure modelling of biomolecules e. g. by AlphaFold2 or comparable applications (e. g. YASARA, MOE, Modeller, H ), machine learning (e. g. via QSAR-based approaches) and molecular dynamic simulation
• Scientific education and understanding of protein chemistry, chromatographic processes, filtration techniques and biophysical methods
• Good knowledge in one of the following programming languages: Python, R (or equivalent also Matlab, Octave, C).
• Basic knowledge in code versioning e. g. git and reproducibility best practices for scientific programming.
• Basic knowledge working with databases (SQL based as well as accessing REST-APIs).
• Strong and collaborative communication skills, team spirit, flexibility and outcome-oriented working
• High level of personal initiative and organizing skills
• Entrepreneurial mindset, economic and analytical thinking
• Fluent in German and English

• Work in a company that offers real value and manufactures medicines for critically ill patients
• Contagious joy in the job as well as a collegial working environment
• Access to exclusive, personalised training through the Global Rentschler Academy
• 30 days of holiday
• Flexible working hours, flexitime account and mobile working
• Responsibility, initiative, further development
• Company health management and pension scheme
• Company child-care centre
• Future-proof industry